AHU-377 (heMicalciuM salt)；calcium salt (2:1)；
CAS:1369773-39-6
Chemical Formula:C48H56CaN2O10
MW:861.04
Availability: R&D; Commercialization
⬤ CAS No.1369773-39-6
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | Sacubitril Calcium |
| CAS No. | 1369773-39-6 |
| Chemical Formula | C48H56CaN2O10 |
| Molecular Weight | 861.04 |
| Related Categories | LCZ696 intermediates; Pharmaceutical Intermediates; Intermediates; Antihypertensive; Chemical raw materials; APIs and intermediates; Pharmaceutical raw materials; Chemical reagents |
| EINECS | 935-847-3 |
| Storage conditions | -20°C |
| Form | Powder |
| Color | White to beige |
| Solubility | DMSO (slightly soluble, heated), methanol (slightly soluble) |
| Melting point | >140°C (dec.) |
| Density | 1.24 g/cm3 at 20°C |
| Vapor pressure | 0.001 Pa at 20°C |
| LogP | -0.66 to 2.9 at 20°C and pH 2-7 |
| Product Name | Sacubitril Calcium (AHU-377 hemicalcium salt) |
| CAS Number | 1369773-39-6 |
| Precautionary Statements | Avoid breathing dust/fume/gas/mist/vapours/spray. Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. |
| Fire Hazard | Low flammability (as a solid pharmaceutical intermediate) |
| Health Hazards | May cause irritation to skin, eyes, and respiratory system if handled improperly. Consult a physician if ingested or inhaled. |
| Environmental Hazards | May have adverse effects on aquatic life if released into the environment. Dispose of according to local regulations. |
| Storage Conditions | Store in a cool, dry place, away from direct sunlight and heat sources. Keep container tightly closed. |
| Handling Precautions | Wear appropriate personal protective equipment (PPE) during handling, including chemical-resistant gloves, eye protection, and protective clothing. |
| Exposure Controls | Maintain good ventilation in work areas. Avoid prolonged or repeated exposure. |
| First Aid Measures | If skin contact occurs, wash thoroughly with soap and water. If eye contact occurs, flush eyes with water and seek medical attention. If ingested, do not induce vomiting and seek medical attention immediately. |
| Disposal Considerations | Dispose of according to local regulations and in compliance with environmental laws. |
| Application | LCZ696 intermediate is an organic synthesis intermediate used in laboratory research and development, as well as chemical pharmaceutical synthesis processes. It is primarily utilized as a standard and reference substance for the development and analysis of sacubitril drugs in analytical chemistry. |
| Uses | Sacubitril is an antihypertensive drug used in combination with valsartan. This combination, known as LCZ696 during clinical trials, is employed in the treatment of heart failure. This product serves as an intermediate and impurity reference substance for the drug and is used in pharmaceutical application testing and related studies. |
| Biological Activity | Sacubitril calcium salt (AHU-377 calcium salt) is a potent neprilysin (NEP) inhibitor with an IC50 value of 5 nM. It is a ke
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