Cetilistat is a drug ingredient mainly used to treat obesity.
| English name | Cetilistat |
| Chemical formula | C25H39NO3 |
| Molecular weight | 401.58 |
| CAS | 282526-98-1 |
| Synonyms | 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one、ATL-962 |
Cetilistat reduces fat absorption primarily by inhibiting the activity of lipases in the gastrointestinal tract. Lipases play a key role in the digestive process, breaking down fat in food so that it can be more easily absorbed by the body.
However, Cetilistat is able to bind to lipases, thereby reducing their activity and reducing fat breakdown and absorption.
Specifically, when Cetilistat enters the body, it selectively binds to lipases (such as pancreatic lipase) in the gastrointestinal tract. This binding inhibits the activity of lipases, resulting in the inability to fully break down fat in food.
As a result, these unbroken fats are excreted from the body with feces, thereby reducing fat absorption and fat accumulation in the body.
Weight loss effect | Reduce fat absorption | Cetilistat is a pancreatic lipase inhibitor that inhibits the activity of pancreatic lipase, reducing the breakdown and absorption of dietary fat. |
| Adjunct to diet and exercise | Cetilistat is usually used along with a low-fat diet and regular exercise to enhance weight loss results. | |
Health Benefits | mprove metabolic markers | When using Cetilistat for weight management, patients may experience improvements in metabolic parameters such as blood pressure, blood sugar, and lipid levels. |
| Reduce obesity-related diseases | Obesity is a significant risk factor for several chronic diseases. By reducing body weight, Cetilistat helps reduce the onset and progression of these diseases. | |
| Improved mental health | Losing weight not only helps improve your appearance, it can also improve your self-confidence and mental health. |
Orlistat is a non-central nervous system-directed obesity treatment drug, mainly used to treat obesity that cannot be controlled by diet and exercise, or obesity combined with high blood sugar, high blood pressure, high blood lipids, and fatty liver.
| English name | Orlistat |
| Chemical formula | C29H53NO5 |
| Molecular weight | 495.73 |
| CAS | 96829-58-2 |
| Synonyms | RO-18-0647 |
As a gastrointestinal lipase inhibitor, orlistat can bind to gastric lipase and pancreatic lipase to form covalent bonds, making these enzymes inactive. Lipase is an enzyme necessary for the breakdown of fat. When they are inhibited by orlistat, they cannot break down the fat in the food into small molecules of glycerol and fatty acids.
Because lipase is inhibited, the fat in the food cannot be effectively broken down into absorbable substances. These unbroken fats will be excreted from the body with feces, thereby reducing the amount of fat absorbed. Orlistat can reduce fat absorption by about 30%.
Weight Management | Orlistat can provide more significant weight loss than relying solely on diet and exercise. |
Body fat reduction | Orlistat inhibits lipase in the gastrointestinal tract, preventing about 30% of dietary fat from being absorbed. |
Improved metabolic markers | Orlistat can significantly reduce blood levels of total cholesterol and LDL cholesterol, which are important for cardiovascular health. |
| Orlistat also has a certain regulatory effect on high-density lipoprotein cholesterol and triglycerides, helping to maintain blood lipid balance. | |
Assists in controlling blood sugar | For obese patients with type 2 diabetes, orlistat can also help lower blood sugar levels and glycated hemoglobin, thereby improving diabetes control. |
Common side effects of Cetilistat may include the following:
Gastrointestinal reactions | Cetilistat may cause gastrointestinal discomfort, such as nausea, vomiting, diarrhea, loss of appetite, etc. These reactions may be due to direct stimulation of the drug to the gastrointestinal tract or affect the normal function of the gastrointestinal tract. |
Nervous system response | Some patients may experience headache, dizziness, depression, drowsiness, mental confusion and other neurological symptoms after using cetilistat. |
Allergic reactions | A small number of patients may have allergic reactions to cetilistat, manifested as rash, itching, urticaria, angioedema, bronchospasm, etc. |
Other side effects | Cetilisito may also cause cardiovascular symptoms, such as palpitations, arrhythmia, etc. In addition, hair loss, proteinuria, abnormal renal function, etc. may also appear as side effects of this drug. |
Since orlistat mainly acts on the gastrointestinal tract and inhibits fat absorption, it may cause a series of gastrointestinal discomfort symptoms.
Gastrointestinal reactions | Increased gastrointestinal flatus、Bowel urgency、ncreased bowel movement and fecal incontinence、Abdominal pain/discomfort |
| Allergic reactions | Rash、Urticaria、Angioneurotic edema |
| Bronchospasm | Symptoms include shortness of breath, wheezing, and in severe cases, suffocation |
| Other side effects | Urinary tract infection、Upper respiratory tract infection、Lower respiratory tract infection |
The side effects of orlistat are mainly concentrated in the gastrointestinal tract, which is directly related to the reduction of fat absorption.
The side effects of cetilistat are relatively wide, including gastrointestinal tract, nervous system, allergic reactions, etc.
It should be made clear that the severity of the side effects of these two drugs is related to many factors, including individual differences, dosage, duration of use, etc. Please be sure to make a comprehensive assessment based on the user’s specific circumstances and the characteristics of the drug.
When comparing which weight loss drug is better, cetilistat or orlistat, we need to consider multiple aspects, including the drug’s weight loss effect, side effects, safety, and applicable population.
In this era of pursuing health and beauty, it is very important to choose a safe and effective weight loss product. .
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