Incoming QC: 3 Checks That Stop Bad Batches on Arrival
A supplier COA is a declaration, not proof. Run incoming QC on arrival: seven checks that decide whether to release or reject a batch.
September 4, 2026
Suzetrigine
VX-548; 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
CAS: 2649467-58-1
Chemical Formula: C21H20F5N3O4
Molecular Weight: 473.4
Availability: R&D; Commercialization
Suzetrigine
⬤ CAS No.2649467-58-1
⬤ Our Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | Suzetrigine |
| CAS No. | 2649467-58-1 |
| Chemical Formula | C21H20F5N3O4 |
| Molecular Weight | 473.4 |
| Related Categories | First-in-class non-opioid analgesic |
| Boiling Point | 591.8±50.0 °C(Predicted) |
| Density | 1.399±0.06 g/cm3(Predicted) |
| Solubility | Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml |
| Acidity coefficient (pKa) | 11.74±0.70(Predicted) |
| Form | solid |
| Color | White to light yellow |
| Mechanism of Action | Suzetraline works by selectively inhibiting NaV1.8 channels, intervening in the pain signal transduction pathway and reducing pain before the signal reaches the brain. This mechanism of action blocks peripheral pathways and does not produce euphoria or excitement in the brain like opioids. |
| Application | VX-548 is an orally active and highly selective NaV1.8 inhibitor with analgesic effects. |
Customer Reviews
Real customer feedback
Michael Carter
Reliable Global Partner
“Tianming Pharmaceutical has redefined reliability for us. Their ability to deliver high-potency APIs and intermediates under tight deadlines—is unmatched. The team’s transparency in documentation and proactive updates make them a stress-free partner. A true backbone for our operations!”
March 18, 2024
Dr. Sofia Alvarez
Outstanding Technical Guidance
“Few suppliers align so perfectly with EU GMP requirements. Tianming’s commitment to audit-ready quality systems, batch traceability, and purity consistency has streamlined our production processes. Their diligence eliminates regulatory risks—a rare advantage in today’s market.”
February 15, 2024
Rajesh Kapoor
Beyond Supplier, A Solutions Partner
“Tianming’s technical team doesn’t just deliver materials—they solve problems. When we faced stability challenges with a niche compound, their scientists proposed a tailored purity adjustment that saved our project timeline. Their agility transforms obstacles into opportunities.”
June 15, 2024
Emily Zhang
Strategic Growth Ally
“Over 5+ years, Tianming has consistently adapted to our evolving needs—whether scaling volumes or supporting custom synthesis projects. Their ethical pricing models and long-term vision make them more than a vendor; they’re integral to our competitive edge.”
April 27, 2024
What's News
Latest news at Tianming
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