Vonoprazan intermediate;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-; 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde; TAK438 Impurity 54; TAK-438( Vonoprazan fumarate) intermediate 3
CAS:881674-56-2
Chemical Formula:C11H8FNO
Molecular Weight:189.19
Availability: R&D; Commercialization
⬤ CAS No.881674-56-2
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde |
| CAS No. | 881674-56-2 |
| Chemical Formula | C11H8FNO |
| Molecular Weight | 189.19 |
| Related Categories | Pharmaceutical intermediates; Flunaprazan intermediates; |
| Melting point | 133 °C |
| Boiling point | 370.6±32.0 °C(Predicted) |
| Density | 1.270±0.06 g/cm3(Predicted) |
| Storage conditions | under inert gas (nitrogen or Argon) at 2-8°C |
| Solubility | Soluble in chloroform (slightly, sonicated), DMSO (slightly), methanol (slightly) |
| Acidity coefficient (pKa) | 14.77±0.50(Predicted) |
| Color | Light brown to brown |
| Form | solid |
| Stability | Hygroscopicity |
| InChI | InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H |
| InChIKey | MQULPEUCGKEHEG-UHFFFAOYSA-N |
| SMILES | N1C(C2=CC=CC=C2F)=CC(C=O)=C1 |
| Safety Information | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent as a potassium competitive acid blocker (P-CAB) in the synthesis of pyrrole derivatives. |
| Application | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde (1-[(2S)-2-pyrrolidinecarbonyl]-pyrrolidine) is a potassium ion competitive acid blocker used to treat acid-related diseases, such as gastric ulcer, duodenal ulcer, and reflux esophagitis. |
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