Sotorasib API;AMG-510 API;Sotorasib cancer treatment;PYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE,6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(1-METHYLETHYL)
CAS:2296729-00-3
Chemical Formula:C30H30F2N6O3
Molecular Weight:560.61
Availability: R&D; Commercialization
⬤ CAS No.2296729-00-3
⬤ Packaging type：20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | Sotorasib |
| CAS No. | 2296729-00-3 |
| Chemical Formula | C30H30F2N6O3 |
| Molecular Weight | 560.61 |
| Related Categories | Inhibitors; Small molecule inhibitors; Raw materials; Anti-tumor drugs; APIs and intermediates |
| Melting point | 730.5±70.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Acidity coefficient (pKa) | 6.52±0.35(Predicted) |
| Storage conditions | Store at -20°C, stored under nitrogen |
| Solubility | DMSO: 100 mg/mL (178.38 mM; requires sonication) |
| Form | Solid |
| Color | White to yellow |
| Water solubility | Water : 33.33 mg/mL (59.46 mM; ultrasonic and adjust pH to 11 with NaOH) |
| InChIKey | NXQKSXLFSAEQCZ-UHFFFAOYSA-N |
| Adverse Reactions | The patients suffered from decreased appetite, diarrhea, fatigue, headache, cough, hot flashes and nausea. No dose-limiting toxicity and drug-related adverse reactions of grade 4 or above were found. |
| Application | Treatment of non-small cell lung cancer. |
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