(2R,4S)-Biphenyl acid；Boc-amino acid derivative；tert-Butoxycarbonyl-protected amino acid；tert-Butyl carbamate amino acid
![(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid](https://www.tianmingpharm.com/wp-content/uploads/2024/08/1012341-50-2.png)
CAS:1012341-50-2
Chemical Formula:C23H29NO4
MW:383.48
Availability: R&D; Commercialization
⬤ CAS No.1012341-50-2
⬤ Packaging type：20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid |
| CAS No. | 1012341-50-2 |
| Chemical Formula | C23H29NO4 |
| Molecular Weight | 383.48 |
Related Categories | LCZ696 intermediate；pharmaceutical intermediate；organic chemical raw material;chemical raw material； |
| Mol | 1012341-50-2.mol |
| EINECS | 1592732-453-0 |
| Melting point | 145-147°C |
| Boiling point | 582.6±50.0 °C(Predicted) |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Storage conditions | 2-8°C |
| Acidity coefficient (pKa) | 4?+-.0.23(Predicted) |
| Form | Solide |
| Color | White to off-white |
| Solubility | Chloroform (slightly soluble), DMSO (slightly soluble), methanol (slightly soluble, sonication) |
| Product Name | (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-Methylpentanoic acid |
| Health Hazards | May cause irritation to skin, eyes, and respiratory system. |
| Environmental Hazards | May be harmful to aquatic life with long-term or repeated exposure. |
| Storage Conditions | Store at 2-8°C, dry and well-ventilated area. Keep away from heat, sparks, and open flames. |
| Stability and Reactivity | Stable under recommended storage conditions. Incompatible with strong acids, bases, and oxidizing agents. |
| First Aid Measures | If swallowed, seek medical attention immediately. If in contact with skin or eyes, rinse thoroughly with water and seek medical advice. |
| Fire Fighting Measures | Use appropriate extinguishing media (e.g., CO2, dry powder, or foam) for flammable materials. |
| Accidental Release Measures | Contain spill and prevent entry into waterways. Collect and dispose of according to local regulations. |
| Handling and Storage Precautions | Wear appropriate personal protective equipment (PPE) during handling. Avoid contact with skin, eyes, and clothing. |
| Exposure Controls/Personal Protection | Use in a well-ventilated area. Wear chemical-resistant gloves, eye protection, and protective clothing. |
| Disposal Considerations | Dispose of according to local regulations and in compliance with environmental laws. |
| Introduction | (2R,4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is a carboxylic acid derivative that can be used as a pharmaceutical intermediate and impurity reference substance. |
| Uses | (2R,4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is a key intermediate for the preparation of sacubitril. |
| Applications | (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is an intermediate in organic synthesis and pharmaceutical research and development and can be used in laboratory research. |
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