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Cortexolone 21-Acetate
Cortodoxon 21-acetate；17-Hydroxy-3,20-dioxopregn-4-en-21-yl acetate;
21-(Acetyloxy)-17-hydroxypregn-4-ene-3,20-dione；
11-Deoxycortisol 21-acetate
CAS: 640-87-9
Chemical Formula: C23H32O5
Molecular Weight: 388.5
Availability: R&D; Commercialization
Cortexolone 21-Acetate
⬤ CAS No.640-87-9
⬤ Our Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | Cortexolone 21-Acetate |
| CAS No. | 640-87-9 |
| Chemical Formula | C23H32O5 |
| Molecular Weight | 388.5 |
| Related Categories | Clascoterone Intermediate Cortodoxone Intermediates |
| Melting Point | 233–235 °C |
| Boiling Point | 537.9 °C (at 760 mmHg; predicted) |
| Density | 1.4 g/cm³ |
| Flash Point | 181.8 °C |
| Refractive Index | 1.558 |
| LogP | 3.38 |
| pKa | 12.59 ± 0.60 (predicted) |
| Appearance/Form | Crystalline solid (typical steroid form) |
| Color | White to off-white |
| Solubility | Sparingly soluble in chloroform; slightly soluble in methanol (when heated) |
| Storage | Refrigerated (2–8 °C) |
| Mechanism of Action | Cortexolone 21‑acetate (CAS 640‑87‑9) acts as a synthetic steroid intermediate and partial agonist of progesterone and glucocorticoid receptors, regulating gene transcription to exert anti‑inflammatory and mineralocorticoid‑modulating effects while serving as a key precursor for cortisone and hydrocortisone production. |
| Application | Cortexolone 21‑acetate (CAS 640‑87‑9) is mainly used as a key pharmaceutical intermediate for synthesizing hydrocortisone, cortisone and other corticosteroid drugs. |
Customer Reviews
Real customer feedback
Michael Carter
Reliable Global Partner
“Tianming Pharmaceutical has redefined reliability for us. Their ability to deliver high-potency APIs and intermediates under tight deadlines—is unmatched. The team’s transparency in documentation and proactive updates make them a stress-free partner. A true backbone for our operations!”
March 18, 2024
Dr. Sofia Alvarez
Outstanding Technical Guidance
“Few suppliers align so perfectly with EU GMP requirements. Tianming’s commitment to audit-ready quality systems, batch traceability, and purity consistency has streamlined our production processes. Their diligence eliminates regulatory risks—a rare advantage in today’s market.”
February 15, 2024
Rajesh Kapoor
Beyond Supplier, A Solutions Partner
“Tianming’s technical team doesn’t just deliver materials—they solve problems. When we faced stability challenges with a niche compound, their scientists proposed a tailored purity adjustment that saved our project timeline. Their agility transforms obstacles into opportunities.”
June 15, 2024
Emily Zhang
Strategic Growth Ally
“Over 5+ years, Tianming has consistently adapted to our evolving needs—whether scaling volumes or supporting custom synthesis projects. Their ethical pricing models and long-term vision make them more than a vendor; they’re integral to our competitive edge.”
April 27, 2024
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