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Baricitinib
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile; INCB28050; LY3009104
CAS:1187594-09-7
Chemical Formula:C16H17N7O2S
MW:371.42
Availability: R&D; Commercialization
Baricitinib
⬤ CAS No.1187594-09-7
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | Baricitinib |
| CAS No. | 1187594-09-7 |
| Chemical Formula | C16H17N7O2S |
| Molecular Weight | 371.42 |
| Related Categories | Small molecule inhibitors; pharmaceutical raw materials; raw materials and intermediates; anti-rheumatoid drugs; chemical raw materials; chemical raw materials; fine chemicals; chemical reagents |
| EINECS | 691-421-4 |
| Storage conditions | -20°C |
| Form | Solid |
| Color | White or off-white |
| Solubility | Soluble in DMSO (up to 30mg/ml) or DMF (up to 50mg/ml) |
| Melting point | 212-215°C |
| Density | 1.56 |
| Acidity coefficient (pKa) | 11.66±0.50 (Predicted) |
Stability | Stable for 2 years from the date of purchase. Its DMSO or DMF solution can be stored at -20°C for up to 3 months. |
| Generic Name | Baricitinib |
| Indication | Treatment of moderate to severe rheumatoid arthritis, severe alopecia areata, and COVID-19 |
| Warnings | – Contraindicated during pregnancy- Not recommended during lactation- May reduce fertility in females |
| Precautions | – Monitor for infections, including serious infections- Evaluate for tuberculosis before and during treatment- Assess for liver enzyme elevations- Consider age, weight, and comorbidities when dosing |
| Special Populations | – Safety and efficacy not established in children under 18 years- Limited clinical experience in patients ≥75 years- Use caution in patients with renal or hepatic impairment |
Adverse Reactions | – Common: Infections, nausea, upper respiratory tract infections- Serious: Serious infections (including pneumonia, sepsis), thrombosis, malignancy, hepatic toxicity- Frequency: Based on clinical trials and post-marketing data |
| Drug Interactions | Potential interactions with immunosuppressants, anticoagulants, and drugs metabolized by CYP2C8 or CYP3A4 |
| Dosage and Administration | – Dosage varies based on indication and patient characteristics- Administer with or without food- Swallow tablets whole; do not crush, chew, or dissolve |
| Storage | Store at room temperature, not exceeding 30°C |
| Overview | Baricitinib is an oral JAK kinase 1 and 2 inhibitor commonly used in adults for the treatment of moderate to severe active rheumatoid arthritis (RA). For rheumatoid arthritis patients who have not previously used biological DMARDS drugs, baricitinib can reduce disease activity. |
| Physical and Chemical Properties | It is a white or off-white crystalline powder, odorless and tasteless. It is slightly soluble in water, soluble in hot water, insoluble in ethanol or acetone, and easily soluble in sodium hydroxide test solution. |
Adverse Reactions | The most common adverse reactions include headache, upper respiratory tract infection, and nasopharyngitis. No opportunistic infections, tuberculosis infections, or gastrointestinal perforations have been observed. |
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Exceptional Product Quality
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June 15, 2023
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June 15, 2023
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June 15, 2023
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