Compound MRTX849；Adagrasib (MRTX-849)；{(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]-methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl}acetonitrile
CAS:2326521-71-3
Chemical Formula:C32H35ClFN7O2
Molecular Weight:604.1
Availability: R&D; Commercialization
⬤ CAS No.2326521-71-3
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | Adagrasib |
| CAS No. | 2326521-71-3 |
| Chemical Formula | C32H35ClFN7O2 |
| Molecular Weight | 604.1 |
| Related Categories | Inhibitors; chemical raw materials; fine chemical products; pharmaceutical raw materials; Belka main product; API |
| Boiling point | 860.2±75.0 °C(Predicted) |
| Density | 1.295±0.06 g/cm3(Predicted) |
| Storage conditions | Store at -20°C |
| Solubility | Dissolved in DMSO: 1.0 (maximum concentration mg/mL); 1.7 (maximum concentration mM) |
| Form | Crystalline solid |
| Acidity coefficient(pKa) | 9.31±0.40(Predicted) |
| Color | White to yellow |
| InChIKey | PEMUGDMSUDYLHU-ZEQRLZLVSA-N |
| Note | This product is a chemical product and is only used for new drug research and development, process research, chemical intermediate reprocessing, etc. |
| Application | It is an anticancer drug targeting KRAS G12C mutation, mainly used to treat solid tumors such as non-small cell lung cancer (NSCLC) and colorectal cancer. |
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