Copovidone, also known as medicinal copovidone VA64 powder, is an important pharmaceutical excipient. It is usually white to milky white powder, odorless, easy to absorb moisture, soluble in water, ethanol and anhydrous alcohol, and has good adhesion, hygroscopicity, film-forming properties and surface activity.
Simply put, when copovidone encounters drug raw materials, it acts like glue, tightly bonding the drug particles together to form a solid tablet. In this way, the tablet can remain intact when taken, ensuring that the active ingredients of the drug can be released evenly.
Let’s take a look at some basic chemical information of copolyvidone：
| Product Name | Copovidone |
| CAS No. | 25086-89-9 |
| Chemical Name | NVP/VAc COPOLYMER, a copolymer of N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) |
| Characteristics | White to pale yellow free flowing powder |
| Molecular formula | (C6H9NO)n(C4H6O2)m |
In the process of drug manufacturing, copolyvidone plays a very important role. It is not only the “super glue” in the adhesive, but also the “invisible cloak” on the coating, and also the “accelerator” of drug dissolution.
Imagine that you have a bunch of small tablet raw materials in your hand. They are like a pile of scattered building blocks. How can you stick them together tightly to form a complete tablet? At this time, copolyvidone is like a skilled “super glue master”.
Copolyvidone is composed of two magical chemicals – N-vinyl pyrrolidone and vinyl acetate. These two substances are like two tacit partners, which together give copolyvidone excellent bonding ability.
When copolyvidone encounters drug raw materials, it is like glue, which tightly bonds the drug particles together to form a solid tablet. In this way, the tablet can remain intact when taken, ensuring that the active ingredients of the drug can be released evenly.
In addition to being a “super glue”, copolyvidone has another important identity – the “invisible cloak” of drug coating.
We all know that during the storage and transportation of drugs, they are easily affected by the external environment, such as moisture, oxygen and light. These external factors are like a group of “troublemakers” that will destroy the stability of the drug and reduce its efficacy. Copolyvidone is like a brave “invisible cloak warrior”, which can tightly wrap around the surface of the drug to form a protective film.
This protective film is like an invisible shield that can resist the invasion of external factors and protect the drug from damage. At the same time, copolyvidone can also control the release rate of the drug, like a careful “time manager”, ensuring that the drug is slowly released at the right time to achieve the best therapeutic effect.
In addition, copolyvidone has a hidden skill – improving the solubility of drugs. It can shorten the distance between drugs and water, making drugs more easily dissolved in water. In this way, drugs can be absorbed by the body faster and exert their efficacy.
There are many benefits to using copolyvidone in medicines. Below we will use a table to let everyone quickly understand the advantages of copolyvidone.
| Benefits | Explanation |
Improved stability and shelf life | Copolyvidone, as a film-forming agent, can be used to prepare film coatings that protect drugs from external environmental influences such as humidity, oxygen and light, thereby improving drug stability and extending shelf life. |
| Optimizing the preparation process of pharmaceutical products | Copolyvidone, as a binder and disintegrant, can simplify the drug preparation process and reduce the preparation cost. |
| Improve the release properties of drugs | Controlled release rate；Improve drug absorption. |
Enhance the flexibility and water absorption resistance of drugs | Copolyvidone has good flexibility and resistance to water absorption, which can reduce the adhesion and deformation problems of drugs during storage and use, and improve the quality and appearance of drugs. |
Improving the safety of medicines | As a pharmaceutical excipient, copolyvidone meets the pharmacopoeia standards and is non-toxic, non-irritating, and has no allergic reactions, thus ensuring the safety of the drug. |
| Copovidone | Other Binders | |
| Hygroscopicity | Lower | Higher |
| Dissolution performance | Broad solubility range | Only suitable for certain solvents |
Plasticity | Better, can adapt to different preparation processes and molding requirements | Poor performance |
Security | Meets pharmacopoeia standards and is non-toxic, non-irritating and non-allergic | There may be certain safety risks |
Copovidone has a high safety profile in the pharmaceutical industry and is strictly regulated. Pharmaceutical companies and regulatory agencies need to work together to ensure that the quality and safety of copovidone in pharmaceutical preparations meet regulatory requirements to ensure the safety of patients’ medication.
Tianming is committed to producing high-quality, safe and reliable copovidone products in strict compliance with the pharmacopoeia standards and guidance of regulatory agencies in various countries.
Through continuous technological innovation and quality control, we ensure that each batch of products meets the highest standards and brings safer and more effective treatment options to patients. Contact us now for free product quotes and purchase options！
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