Empagliflozin(W.S); Empaglifloin; Empagliflozin API; BI-10773; BI 10773; BI10773; CS-798; EMPAGLIFLBZIN
CAS: 864070-44-0
Chemical Formula: C23H27ClO7
MW: 450.91
Availability: R&D; Commercialization
⬤ CAS No. 864070-44-0
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| Product Name | Empagliflozin |
| CAS No. | 864070-44-0 |
| Chemical Formula | C23H27ClO7 |
| Molecular Weight | 450.91 |
| Related Categories | Empagliflozin; APIs and intermediates; hypoglycemics; Empagliflozin API; APIs; hypoglycemics; small molecule inhibitors; pharmaceutical APIs; hypoglycemics |
| EINECS | 620-176-8 |
| Melting point | 665℃ |
| Storage conditions | 2-8°C |
| Solubility | Insoluble in water; ≥20.75 mg/mL in DMSO; ≥7.06 mg/mL in ethanol solution, ultrasonic |
| Form | Solid |
| Color | White |
| Density | 1.398 |
| Stability | Hygroscopicity |
| Flash point | 356℃ |
| Acidity coefficient (pKa) | 13.23±0.70(Predicted) |
| Product Name | Empagliflozin |
| Hazard Statements | H317: May cause an allergic skin reaction. H319: Causes serious eye irritation. |
| Precautionary Statements | P261: Avoid breathing dust/fume/gas/mist/vapours/spray.P272: Contaminated work clothing should not be allowed out of the workplace. |
| Main Component | Empagliflozin (SGLT2 inhibitor) |
| Concentration | 100% (active pharmaceutical ingredient) |
| Stability Conditions | Store in a well-ventilated area, away from heat and moisture. |
| Incompatibility | Avoid contact with strong oxidizing agents. |
| Conditions to Avoid | Exposure to moisture, heat, and direct sunlight. |
| Routes of Exposure | Inhalation, ingestion, skin contact |
| Effects | May cause skin irritation, eye irritation, allergic reactions. Consult medical advice if swallowed. |
| First Aid Measures | Eye contact: Rinse immediately with plenty of water. Skin contact: Wash with soap and water. Ingestion: Seek medical attention. |
| Handling Precautions | Wear appropriate protective clothing and gloves. Avoid prolonged skin contact. |
| Storage Conditions | Store in a cool, dry place, protected from light. Keep container tightly closed. |
| Personal Protective Equipment | Protective clothing, gloves, and eye protection during handling. |
| Waste Disposal | Dispose of in accordance with local regulations and waste management guidelines. |
| Overview | Empagliflozin is a sodium-dependentglucose cotransporter 2 (SGLT-2) inhibitor. SGLT-2 inhibitors are a new type of hypoglycemic drug that mainly inhibits SGLT-2 expressed in the kidney, reduces glucose reabsorption by the kidney, increases glucose excretion in the urine, and thus reduces plasma glucose levels. Its hypoglycemic effect is independent of β-cell function and insulin resistance. |
| Empagliflozin | It is used to treat adult patients with type 2 diabetes who have not achieved adequate glycemic control with diet and exercise to improve glycemic control. |
| Adverse Reactions | Empagliflozin has a low incidence of adverse reactions. Compared with the placebo group, the incidence of common adverse reactions was 2%, including urinary tract infection, female reproductive system fungal infection, upper respiratory tract infection, polyuria, dyslipidemia, joint pain, male reproductive system fungal infection, hypoglycemia, and nausea. Other adverse reactions less than 2% are common in thirst (polydipsia, polydipsia), hypovolemia, and renal impairment. |
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