4,6-dichloro-2-(propylthio)-5-PyriMidinaMine;TecagrelorInterMediate3;5-PyriMidinaMine,4,6-dichloro-2-(propylthio)-
CAS:145783-15-9
Chemical Formula:C7H9Cl2N3S
MW:238.14
Availability: R&D; Commercialization
⬤ CAS No.145783-15-9
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | 4,6-dichloro-2-propylthiopyrimidine-5-amine |
| CAS No. | 145783-15-9 |
| Chemical Formula | C7H9Cl2N3S |
| Molecular Weight | 238.14 |
Related Categories | ticagrelor intermediates; API intermediates; APIs; pharmaceutical raw materials; Pyrimidine; Ticagrelor raw material two; pharmaceutical intermediates; Intermediates |
| EINECS | 808-051-8 |
| Storage conditions | Keep in dark place,Sealed in dry,Room Temperature |
| Form | Powder to lump to clear liquid |
| Color | White or colorless to brown |
| Solubility | Soluble in methanol |
| Melting point | 334.1±37.0 °C(Predicted) |
| Density | 1.44 |
| Acidity coefficient (pKa) | -3.46±0.12(Predicted) |
| Water solubility | 100mg/L at 22℃ |
| Product Name | 4,6-dichloro-2-propylthiopyrimidine-5-amine |
| Hazards Identification | – GHS Classification: Not classified for physical hazards- Health Hazards: Skin Corr. 2 / Eye Dam. 2A- Environmental Hazards: Not classified |
| Precautions | – Wash hands thoroughly after handling- Wear protective gloves/eyewear/face shield |
| First Aid Measures | – Eyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. If irritation persists, seek medical attention.- Skin: Immediately remove contaminated clothing and flush skin with plenty of water for at least 15 minutes. If skin irritation occurs or persists, seek medical attention.- Inhalation: Remove to fresh air. Keep at rest in a position comfortable for breathing. If feeling unwell, seek medical attention.- Ingestion: If swallowed and you feel unwell, seek medical advice immediately and show this container or label. Rinse mouth. |
| Fire Fighting Measures | – Suitable Extinguishing Media: Dry powder, foam, water spray, carbon dioxide- Special Hazards Arising from the Substance or Mixture: May release toxic gases in fire.- Fire Fighting Instructions: Fight fire remotely due to the risk of explosion. Use fire-fighting procedures that are appropriate to local circumstances and the surrounding environment. |
| Accidental Release Measures | – Personal Precautions: Wear protective equipment. Evacuate personnel from dangerous areas and keep upwind.- Containment and Cleanup: Contain spill with sand or inert absorbent material. Collect in closed containers for disposal. Prevent entering into drains/sewers/waterways. |
| Handling and Storage | – Handle with care. Keep container tightly closed.- Store in a cool, well-ventilated area away from incompatible substances such as oxidizers. |
| Exposure Controls/Personal Protection | Use appropriate engineering controls and personal protective equipment to minimize exposure. |
| Stability and Reactivity | – Stability: Normally stable.- Incompatibility: Oxidizers.- Hazardous Decomposition Products: May form carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, hydrogen chloride in a fire. |
| Disposal Considerations | Dispose of according to local, regional, national, and international regulations. Consult with environmental protection agency for guidance. |
| Apply | 4,6-Dichloro-2-(propylthio)-5-aminopyrimidine is an intermediate in organic synthesis and pharmaceutical intermediates. It can be used in laboratory research, chemical and pharmaceutical R&D processes, and is primarily used as an intermediate for the anticoagulant API, ticagrelor. |
| Use | 4,6-Dichloro-2-(propylthio)-5-aminopyrimidine is a pharmaceutical intermediate used as an intermediate for the anticoagulant API, ticagrelor. |
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