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(R,E)-4-Boc-amino-2-methyl-5-(biphenyl-4-yl)-2-pentenoic acid LCZ696 intermediate
(2E,4R)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoic acid
![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](https://www.tianmingpharm.com/wp-content/uploads/2024/08/1012341-48-8.png)
CAS:1012341-48-8
Chemical Formula:C23H27NO4
MW:381.46
Availability: R&D; Commercialization
(R,E)-4-Boc-amino-2-methyl-5-(biphenyl-4-yl)-2-pentenoic acid LCZ696 intermediate
⬤ CAS No. 1012341-48-8
⬤ Packaging type：20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | (R,E)-4-Boc-amino-2-methyl-5-(biphenyl-4-yl)-2-pentenoic acid LCZ696 intermediate |
| CAS No. | 1012341-48-8 |
| Chemical Formula | C23H27NO4 |
| Molecular Weight | 381.46 |
| Related Categories | LCZ696 intermediate; pharmaceutical intermediate; impurity reference substance; chemical reagent; LCZ696; intermediate; intermediates |
| Mol | 1012341-48-8.mol |
| Melting point | 188 – 191°C |
| Boiling point | 595.6±50.0 °C(Predicted) |
| Density | 1.132±0.06 g/cm3(Predicted) |
| Vapor pressure | 8.4-839.931Pa at 20℃ |
| Storage conditions | -Sealed in dry,Room Temperature |
| Solubility | Soluble in DMSO (a little), methanol (a little) |
| Acidity coefficient (pKa) | 4.67±0.19(Predicted) |
| Form | Solid |
| Color | White to off-white |
| LogP | 2.2-3.6 at 25℃ and pH2.5-7 |
| Personal protection | Wear protective equipment: Wear appropriate protective clothing, chemical protective glasses, chemical protective gloves and protective shoes during operation. If dust may be generated, wear a dust mask. Avoid skin contact: The product may irritate the skin and direct contact with the skin should be avoided as much as possible. If contact occurs accidentally, rinse immediately with plenty of water and seek medical help. Avoid eye contact: Prevent the product from splashing into the eyes. If it happens, rinse the eyes immediately with plenty of water and seek medical help. |
| Environmental Control | Good ventilation: Maintain good ventilation conditions in the operating area to reduce the concentration in the air. Prevent leakage: Measures should be taken to prevent product leakage, such as using sealed containers and leakage emergency treatment equipment. |
| Introduction | (R,E)-4-Boc-amino-2-methyl-5-(biphenyl-4-yl)-2-pentenoic acid LCZ696 intermediate is a key intermediate in the synthesis of various drugs, especially in the synthesis of LCZ696 (an angiotensin receptor-neprilysin inhibitor used to treat heart failure). This compound is widely used as an important intermediate. |
| Uses | An intermediate used in the synthesis of certain drugs, such as LCZ696 (also known as sacubitril-valsartan). LCZ696 is a combination preparation consisting of the enkephalinase inhibitor sacubitril and the angiotensin receptor antagonist valsartan, mainly used to treat cardiovascular diseases such as heart failure and hypertension. |
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