1,6-Naphthyridine-3-carboxamide,4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-, (4S)-；BAY 94-8862
CAS:1050477-31-0
Chemical Formula:C21H22N4O3
MW:378.42
Availability: R&D; Commercialization
⬤ CAS No.1050477-31-0
⬤ Packaging type：
20kg barrel；5kg barrel；1kg bag；500g bag ; Customized Packaging
| English Name | Finerenone |
| CAS No. | 1050477-31-0 |
| Chemical Formula | C21H22N4O3 |
| Molecular Weight | 378.42 |
| Related Categories | Finerenone intermediates |
| Mol | 1050477-31-0.mol |
| Boiling point | 554.7±50.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Storage conditions | -20°C |
| Solubility | DMF: 10 mg/ml DMSO: 3 mg/ml Ethanol: insol PBS (pH 7.2): insol |
| Acidity coefficient (pKa) | 14.76±0.40(Predicted) |
| Form | Solid |
| Color | White to off-white |
| Maximum wavelength (λmax) | 255 nm |
| Adverse Reactions | Common: Dizziness, fatigue, hypotension, hypokalemia (low potassium levels) |
| Less common: Gastrointestinal irritation, allergic reactions, renal impairment | |
| Drug Interactions | May interact with CYP3A4 inhibitors, increasing the risk of adverse effects |
| Monitoring | Regular monitoring of potassium levels and renal function recommended |
| Special Populations | Elderly patients may not require dose adjustment; caution in patients with hepatic or renal impairment |
| Introduction | Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. |
| Uses | Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used to treat diabetic nephropathy, chronic kidney disease and end-stage renal disease, and can reduce proteinuria and improve glomerular filtration rate in patients. |
| Biological Activity | Finerenone (FIN, BAY94-8862) is a highly selective, orally active non-steroidal antagonist of mineralocorticoid receptor (MR) with an IC50 value of 18nM. Finerenone has the potential to study cardiorenal diseases such as type 2 diabetes and chronic kidney disease. |
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